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Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose
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doi: 10.1038/s41586-024-07373-5 135 BalasubramanianAHsuAYGhimireLTahirMDevantPFontanaPet al
Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF- signaling in regulatory T cells
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However, science is particularly interested in it because of its many physiological, endocrine and modulatory effects, such as its ability to alter corticotropin levels, inhibit somatostatin secretion, normalize blood pressure, reduce stress, influence sleep rhythms, or chronic pain perception
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