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Coca-Pelaz A, Rodrigo JP, Agaimy A, Williams MD, Saba NF, Nuyts S, Randolph GW, Lpez F, Vander Poorten V, Kowalski LP, Civantos FJ, Zafereo ME , Mkitie AA, Cohen O, Nixon IJ, Rinaldo A, Ferlito A
Cell 174 , 780784 (2018)
Nature 464 (7288), 520528
Research results are mixed
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Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]
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