Food & Drug Administration Center for Drug Evaluation and Research (CBER)
Mann K, Torup L, Srensen P, Gual A, Swift R, Walker B, et al
Generic alternatives typically become available only after patent expiration and FDA approval of abbreviated new drug applications (ANDAs), a process that may take several years from the original approval date
GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production
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Two additional MTHFD1-related genes, MTHFD1L and MTHFD2L encode mitochondrial NADP + -dependent enzymes