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The absence of clinical benefit in EVOKE is consistent with the interpretation that central pharmacodynamic effects are sub-therapeutic, and that the mechanistic pathways proposed on the basis of preclinical data may not be meaningfully engaged in vivo in humans
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Additionally, retatrutide showed significant improvements from baseline across certain cardiovascular risk factors, including waist circumference, non-HDL cholesterol, triglycerides, systolic blood pressure and high-sensitivity C-reactive protein (hsCRP)
Recent anecdotal reports have raised concern that delayed gastric emptying associated with GLP-1 receptor agonists can increase the incidence of regurgitation and subsequent aspiration of stomach contents during general anesthesia and deep sedation resulting in serious lung injury
