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Metformin carries a rare risk of lactic acidosis, a serious buildup of acid in the blood, especially in people with kidney issues

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In this global registration trial, where 84.0% of participants had a baseline BMI of 35 kg/m, each dose of retatrutide (9 mg and 12 mg) met all primary and key secondary endpoints, delivering significant weight loss and improvements in pain and physical function at 68 weeks using both the efficacy and treatment-regimen estimands

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Dalal M, Ferrucci L, Sun K, Beck J, Fried LP, Semba RD