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It can effectively scavenge excessive reactive oxygen free radicals in the body, protect the normal structure and function of cells and mitochondria, and prevent the occurrence of lipid peroxidation, thus playing a role in preventing cognitive dysfunction in diabetes (113)

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It was also found that nose-to-brain delivery of L-penetratin/exendin-4 can promote the insulin signaling pathway only in the presence of adequate levels of insulin to stimulate insulin receptors in the brain (Kamei et al., 2018)