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For instance, when peripheral tissues become inflamed, the related signals might be transmitted to the brain through these receptors on the neurons, and the brain could then respond to these signals via neural pathways, thus regulating the level of peripheral inflammation

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Neurological and systemic effects in animal models Preclinical research has examined BPC-157 beyond musculoskeletal tissue

For example, S.aureus triggers an inflammatory phenotype of keratinocytes with inflammatory cytokine release, inflammasome activation and AMP production, also causing keratinocyte death [55]

doi: 10.2337/DC18-2282 244 Int VeldP

Preclinical animal models test whether those cellular processes may appear in organized tissue systems