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By acting on GLP-1 receptors in the brain and pancreas, it contributes to reducing hunger and maintaining a normal blood glucose level
The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy
Phase 2 Trial Results (NEJM 2023) The landmark Phase 2 trial enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27) but without diabetes
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