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In TNBC, high expression of ATF4 and Myc is associated with overexpression of SLC1A5 and indicates poor survival outcomes 77
GLP-1RAs improve glucose uptake in cardiomyocytes through dual mechanisms: triggering AMPK activation to facilitate GLUT4 translocation to the cell membrane and regulating the insulin signaling pathway to upregulate GLUT4 expression (79, 80)
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Fish Shellfish Immunol 41:6469
Conclusion: The cardioprotective effects and low risk of hypoglycemia of GLP-1 RAs make them preferred agents in any multidisciplinary approach aiming to reduce CV disease burden and improve prognosis
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