Primary Phase 2 Obesity Trial: Jastreboff AM, Aronne LJ, Ahmad NN, et al
Potential causes include: Excessive supplementation Liver disease Certain types of leukaemia or cancers Kidney disease High levels require further investigation to rule out underlying medical conditions
Risk Factors for PA and B12 Deficiency pernicious-anaemia-society
Since the vitamin bypasses the digestive system, you benefit from maximum absorption and effectiveness
There is no human trial that sets a timeline, so reports are anecdotal and drawn from animal research
[1] The authors reported that methylquinolinium analogs with primary-amine substitutions displayed high permeability from passive and active transport across membranes, measured using two standard in-vitro models: the parallel artificial membrane permeability assay (PAMPA) and Caco-2 human intestinal cell monolayers