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A number of functions, including nerve growth, brain function, and red blood cell production, are dependent on vitamin B12
Eventually, this can lead to a deficiency in vitamin B12
PMID: 18480812
Receptors have time to reset between signals, potentially maintaining sensitivity over longer treatment periods
Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose
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