Low cortisol levels can lead to an increase in inflammation, which can negatively impact methylation and impair detoxification mechanisms
Doubling daily KLOW intake (5 mg instead of 2.5 mg) produces stronger receptor downregulation without proportional metabolic benefit and may trigger transient side effects elevated heart rate, jitteriness, or sleep disruption if the double dose occurred in the evening
Jpn J Food Chem Saf 28(2):6370 Gupta SK et al (2014) Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats
Those descriptions should be handled carefully because individual outcomes and study conditions can vary
To get the FDA to approve the meds as sleep apnea treatments and encourage insurance companies to cover them as such drug makers need to prove the connection, though
Contact your provider immediately for severe or alarming symptoms