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Once the pen is opened, even if it was previously refrigerated, the storage instructions change to room temperature with a much shorter lifespan, as detailed in the How long can semaglutide stay out of the fridge? section

Before any planned surgeries/procedures, inform health care providers that you are using this drug

Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study

Flohe L, Otting F

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Staying hydrated, following a balanced diet, and monitoring for symptoms are all important preventive measures