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At such therapeutic concentrations VPA is 8090% bound to plasma proteins, but the percentage decreases at higher VPA levels

however, it can take several months to observe notable changes

Any substance you take orally needs to travel through your gastrointestinal tract before your body can absorb it, so it often takes a while to feel the benefits

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Topiramate may cause metabolic acidosis which can cause kidney stones, weak bones, harm to an unborn baby, and growth problems in children