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Similarly, in male rats with type II diabetes, administration of liraglutide selectively promoted the enrichment of short-chain fatty acid (SCFA)-producing taxa, including Bacteroides , Lachnospiraceae, and other beneficial probiotic species

The short-acting segment, while still used in specific patient populations, is experiencing slower growth due to lower compliance rates and less favorable weight loss results compared to long-acting alternatives

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Retatrutide goes further by also activating glucagon receptors, which may increase energy expenditure and fat breakdown alongside appetite suppression

This potential is exemplified by the therapeutic efficacy of the dual agonist tirzepatide 14