S., Debom, G
These studies suggest that GLP-1 and its receptor play a role in the pathophysiology of congenital hyperinsulinism and that targeting the GLP-1 receptor may be an effective treatment approach for this condition ( ATP hyperinsulinism and decreases glucose infusion rate requirements in infants with K ATP hyperinsulinism ( Role of GLP-1 in Hyperinsulinemic Hypoglycemia Secondary to Gastric Surgery Plasma glucose homeostasis, particularly in the post-prandial state is altered after gastric surgery, including gastrectomy, fundoplication, and bariatric procedures ( via increased GLP-1 release potentiating insulin secretion
10.1016/j.ccell.2018.02.005 154 LocasaleJ
A very large fraction of published binding constants for melanocortin ligands, including those for cyclic analogues, peptidomimetics and candidate subtype-selective compounds, are reported as inhibition of I-NDP-alpha-MSH binding to membranes from cell lines stably expressing a single human receptor subtype
de Andrade KQ, Moura FA, dos Santos JM, de Arajo OR, de Farias Santos JC, Goulart MO
J Nanobiotechnology , 23 (1)