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This metabolic disease involves defects in insulin secretion and action, and is closely linked to obesity, genetic factors, and metabolic inflammation, and its complex pathologic mechanisms are driving the deepening of cutting-edge research in endocrine medicine

A recent report showed that NAFLD patients with intestinal barrier damage and increased intestinal permeability are characterized by more severe disease status, such as worse liver dysfunction, hyperlipidemia, liver fat deposition, and insulin resistance