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In pregnant women, periodontitis induces synergistic changes in their microbial profiles via the oral-gut axis, with positive correlations between oral pathogens and specific gut bacteria such as Coprococcus , alongside competitive interactions with other gut genera like Lachnoclostridium , collectively reshaping the maternal microbial ecosystem network ( Butyribacter showed positive correlations with neuroactive metabolites L-Asparagine, while these metabolites exhibited inverse correlations with expression of neuroinflammatory genes Tbx and Arhgdib, demonstrating how tooth loss-induced depletion of Butyribacter led to reduced levels of neuroprotective metabolites (particularly L-Asparagine), which subsequently resulted in upregulation of neuroinflammatory markers (Tbx1 and Arhgdib), thereby establishing a mechanistic pathway from tooth loss to neuroinflammation through the oral-gut-brain axis ( Even though these correlation values cannot directly inform the underlying mechanisms shaping the community structure or confirm the existence of interactions among microbes, the main strength of co-occurrence networks is the ability to summarize a vast array of pairwise associations into network elements (comprised of edges and nodes) and features (such as degree, closeness or betweenness centrality) to generate testable hypotheses

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[10] Oxidative Stress Modulation and Gene Expression GHK-Cu and BPC-157 have each been examined for their potential to moderate oxidative stress and influence gene expression patterns in laboratory models, with proposed downstream implications for cellular repair signaling and structural protein synthesis

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All animal studies were approved by the Animal Care and Use Committee of the Yonsei University College of Medicine (No