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Based on animal reproduction studies showing fetal harm at clinically relevant exposures, the FDA recommends that semaglutide should be discontinued at least 2 months before a planned pregnancy due to its long washout period (approximately 5 weeks after the last dose)

Interface Focus, 7 (6), 20170030

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Oxid Med Cell Longev 2021:7382900 Zhang Y, Chen D, Wang D et al (2022) Moderate aerobic exercise regulates follicular dysfunction by initiating brain-derived neurotrophic factor (BDNF)-mediated anti-apoptotic signaling pathways in polycystic ovary syndrome

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