Pain may shift from constant to activity-related, then diminish further
Preclinical cartilage evidence Kwon and Park 2015 in Annals of Clinical and Laboratory Science reported that intra-articular AOD-9604 plus hyaluronic acid in a rabbit knee osteoarthritis model improved cartilage histology and reduced lameness compared with hyaluronic acid alone
Instead, modified activity that avoids aggravating movements while maintaining baseline function typically produces better outcomes
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