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Both RFK and FLAD1 reside in the cytosol and within mitochondria, allowing newly formed FAD to accumulate in the mitochondrial matrix, where it serves as an essential co-factor for numerous flavoproteinsincluding ETF-DH, AIFM1, multiple acyl-CoA dehydrogenases, and glutathione reductase (Figure 1) (60)
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This innovative pairing creates synergistic effects that enhance nitric oxide production and stability beyond what either ingredient can achieve alone
Science 287 , 22622267 (2000)
GoldbergRFWilliamGAustenJZhangXMuneneGMostafaGet al
Obes Rev 10, 178193, doi: 10.1111/j.1467-789X.2008.00544.x (2009)
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