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I look at four things first: how quickly coverage needs to start, how long it needs to last, how sensitive the patient is to appetite or sleep disruption, and whether a steadier effect matters more than flexibility

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Significant anti-inflammatory effects were shown by a high dose of semaglutide, which caused the microglia polarization shifting to M2 as shown by lessening the concentrations of TNF- and i-NOS to 38.29 and 43.48%, respectively, in contrast to elevating arginase-1 and IL-4 to 1.89- and 2.55- folds, respectively, in comparison with reserpine group (Fig