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doi: 10.1016/j.tem.2022.05.003 34

oral semaglutide, lowering A1C by an average of 1.9% (12 mg) and 2.2% (36 mg) compared to 1.1% (7 mg) and 1.4% (14 mg) with oral semaglutide at 52 weeks using the efficacy estimand

Semaglutide Clinical Trial Results (STEP Program): STEP 1 Trial (Wegovy 2.4 mg): Participants: 1,961 adults with obesity or overweight with comorbidities Duration: 68 weeks Average Weight Loss: 14.9% of body weight Placebo Group: 2.4% weight loss Patients Losing 5% or More: 86.4% Patients Losing 10% or More: 69.1% Patients Losing 15% or More: 50.5% STEP 2 Trial (Participants with Type 2 Diabetes): Average Weight Loss: 9.6% of body weight Duration: 68 weeks Notable: Lower weight loss in diabetic population, which is typical STEP 3 Trial (With Intensive Behavioral Therapy): Average Weight Loss: 16.0% of body weight Duration: 68 weeks Notable: Highest weight loss when combined with intensive lifestyle intervention STEP 4 Trial (Maintenance Study): Finding: Participants who stopped semaglutide regained most of their lost weight Continuation Group: Maintained weight loss and continued to lose more weight Conclusion: Suggests long-term use is needed to maintain results Tirzepatide Clinical Trial Results (SURMOUNT Program): SURMOUNT-1 Trial (Zepbound 15 mg highest dose): Participants: 2,539 adults with obesity or overweight Duration: 72 weeks Average Weight Loss (15 mg dose): 22.5% of body weight Average Weight Loss (10 mg dose): 21.4% of body weight Average Weight Loss (5 mg dose): 15.0% of body weight Placebo Group: 2.4% weight loss Patients Losing 5% or More (15 mg): 96% Patients Losing 10% or More (15 mg): 89% Patients Losing 15% or More (15 mg): 78% Patients Losing 20% or More (15 mg): 63% SURMOUNT-2 Trial (Participants with Type 2 Diabetes): Average Weight Loss (15 mg dose): 15.7% of body weight Duration: 72 weeks Notable: Diabetic participants still achieved substantial weight loss SURMOUNT-3 Trial (Maintenance After Initial Weight Loss): Finding: Continued tirzepatide after initial weight loss led to additional 5.5% weight loss Withdrawal Group: Regained 14% of weight Conclusion: Ongoing treatment maintains and continues weight loss progress Direct Comparison: Real-World Weight Loss Examples: Starting Weight: 250 pounds Semaglutide (14.9% loss): Final weight ~213 pounds (37 pounds lost) Tirzepatide (22.5% loss): Final weight ~194 pounds (56 pounds lost) Difference: 19 additional pounds lost with tirzepatide Starting Weight: 200 pounds Semaglutide (14.9% loss): Final weight ~170 pounds (30 pounds lost) Tirzepatide (22.5% loss): Final weight ~155 pounds (45 pounds lost) Difference: 15 additional pounds lost with tirzepatide Important Context: Clinical trial results represent averages

Effects of nutritional restriction during laying period of fat and lean line broiler breeder hens on meat quality traits of offspring

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