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Consistent with these studies, a recent study in healthy NS workers demonstrated that moderate alcohol consumption further altered peripheral clock gene amplitude in CLOCK, BMAL1, PER1, CRY1, and CRY2, and it was associated with increased colonic permeability, highlighting the compounding effects of environmental circadian disruption and lifestyle factors on peripheral clock gene regulation 143

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2023, Aug;94:104729 Ruffieux H, Hanson AL, Lodge S, Lawler NG, Whiley L, Gray N, et al