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In some cases, significant weight loss and energy deficit can lead to functional hypothalamic amenorrhoea, where the brain temporarily reduces signals to the ovaries
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P = 0.02) (Fig
This gradual increase reduces nausea, allows smoother digestive adaptation, and helps patients maintain consistent treatment without interruption
Rapid weight loss is a significant contributor to loose skin, as collagen production, which keeps the skin tight and provides structure, cannot keep up with fat loss
At week 72, primary endpoints showed 62.9% of people treated with 2.4 mg semaglutide achieved resolution of steatohepatitis with no worsening of liver fibrosis compared to 34.1% on placebo
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