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Researchers prefer to study acetyl-L-carnitine because it is better absorbed in the small intestine than other forms, and more efficiently crosses the blood-brain barrier

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In rare cases, it has also been associated with confusion, dizziness, tiredness and fainting among others.

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However, efficient and targeted intra-articular gene delivery remains a considerable technical challenge, primarily due to the dense extracellular matrix (ECM) of cartilage, rapid clearance of joint fluid, and limited cellular uptake

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