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JAHA 6 , e0036203 (2017)

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Semaglutides introduction of a fatty acid side chain at position 26 Lys allows reversible binding to plasma albumin and reduces renal clearance, and substitution of amino acids at positions 8 and 34 with Aib and Arg avoids its degradation by DPP-4 and prevents fatty acid binding at the wrong site, resulting in a once-weekly dosing (Lau et al., 2015

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Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial