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Under hypoxic or hyperglycemic conditions, the accumulation of HIF1 markedly drives renal tubular cell ferroptosischaracterized by HO1/TFRC upregulation, iron overload, and lipid peroxidation
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Studies are planned to further evaluate NPI-001 and NPI-002 as potential treatments for AMD and Stargardt disease
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doi: 10.1021/cb400380s 105 LewinARReidLEMcMahonMStarkGRKerrIM
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