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In addition, miR-146a inhibition subsequently increases IL-6 expression, creating a regulatory loop that down-regulates IL-1/TNF- production [5]
Although both semaglutide and cagrilintide induce satiety, they exert their effects in different regions of the brain, suggesting a synergistic effect on appetite regulation, warranting the investigation of these drugs as a combination therapy
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However, given that this study did not measure IL-6 or IL-10, it is unclear where there was also a concomitant increase in anti-inflammatory molecular factors to counteract this response
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