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Highlights GLP-1 medicines reduce fat and liver mass more rapidly than skeletal muscle (SKM) Running performance is maintained or improved in mice on GLP-1 medicine GLP-1 medicine modifies the SKM proteome despite similar weight loss as calorie restriction Patients on GLP-1 medicine slightly reduce SKM mass but largely maintain strength Summary The large decrease in body weight with glucagon-like peptide-1 (GLP-1) medicines raises concern about a loss of lean body mass (LBM) and skeletal muscle
Glutathione also plays a major role in supporting immune function
December 2025: The FDA approved a once-daily oral Wegovy pill (semaglutide 25 mg) for long-term weight reduction and cardiovascular risk mitigation
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