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Notably, higher semaglutide dosage (mg) emerged as an independent predictor of these adverse musculoskeletal changes

In a separate model, hMSC stimulation with 10 nM Liraglutide for 72 h led to increased levels of the anti-inflammatory cytokines interleukin-10 (IL-10) and tumor necrosis factor-stimulated gene 6 ( TSG-6 ) in culture supernatant

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The onset of treatment or an elevation in dosage can often accentuate these symptoms due to increased sensitivity during such times