Significant increases in cysteinyl adducts of L-DOPA, DA, and DOPAC have been found in substantia nigra of PD patients, suggesting the cytotoxic nature of DA oxidation (Spencer et al., 1998)
Others notice no change
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Renal function is another important consideration
In many mammals, glycine is rate-limiting for glutathione production under chronic toxic stress
Moreover, females may be more likely to experience gastrointestinal side effects like nausea and vomiting, as well as headache and dizziness