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The complete conservation of GLP-1 across all mammalian species underscores its critical physiological role (29, 30) [ Figure 2 ]

And the results are some of the most compelling ever seen in a trial of this type

In rodent studies, polyphenols from green tea significantly reduced IGF-1

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The ranking of therapies is based on their pathway-targeting effectiveness within the DM2-AD comorbidity network, and while metformin demonstrates the highest engagement with key neuroprotective mechanisms, and semaglutide among the least, this does not imply complete inefficacy of lower-ranked therapies