This chronic activation releases a storm of pro-inflammatory cytokines (like IL-6 and TNF-alpha) that disrupt normal neuronal communication and impair the blood-brain barrier
But that is very difficult, which is why rebound happens. Sometimes he tells patients to take photos of themselves during treatment or keep food records, so that when the injections stop, they have something to hold on to
In fact, obesity and low testosterone can create a sort of positive feedback loop: obesity lowers testosterone, which in turn can lead to less muscle mass, which can lead to further weight gain
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This leads to more efficient fat oxidation and a visible reduction in body fat when paired with proper diet and training