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FDA approval requires completed clinical trials proving safety and effectiveness

So B12 deficiency and cobalamin deficiency are synonymous

However, their effect on the neural circuits in the brain that drive hedonic feeding (eating driven by pleasure, reward or sensory appeal) remains mostly unknown, said the researchers

[7] Although such traditional biomarkers are useful to reflect the levels of liver injuries, they are limited in their ability to distinguish DILI from other liver damages and response prognosis, which making them not ideal as biomarkers

While some people need them in the long term

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