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Zhang H, Qin F, Liu A, Sun Q, Wang Q, Xie S, et al
The features of aging comprise 12 multiple interrelated biological processes, including primary hallmarks (genomic instability [13], telomere shortening [14, 15], epigenetic alterations [16], loss of proteostasis [17, 18], and dysfunction of macroautophagy [19]), and antagonistic hallmarks (cellular senescence [20], mitochondrial dysfunction [21, 22], deregulated nutrient sensing [23]), integrative hallmarks (stem cell exhaustion [24], altered cellular communication [25], chronic inflammation [26, 27, 28, 29], and dysbiosis [30, 31])
Maffioletti, E., Zanardini, R., Gennarelli, M
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Oral tranexamic acid use for melasma constitutes off-label use and should only be undertaken under direct medical supervision
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