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Semaglutide therefore provides a further treatment option for patients for whom metformin and lifestyle changes have failed and who are still considered uncontrolled on liraglutide or dulaglutide

However, the buccal area offers a larger surface for absorption and experiences less saliva washout than the sublingual space

In fact, weight loss often reduces inflammation and may improve autoimmune symptoms

These include the cost of the medication, potential side effects such as gastrointestinal disturbances and increased risk of thyroid tumors, the unestablished long-term safety in non-diabetic individuals, and limited availability due to high demand

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