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To inactivate LS GLP-1R neurons, we injected AAV expressing double-floxed EGFP and TeNT (AAV-DIO-EGFP-2A-TeNT) into the bilateral LS of GLP-1R-ires-Cre mice to achieve specific expression of EGFP-2A-TeNT in LS GLP-1R neurons (Figure 3A and Supplemental Figure 6C)

Nature 575 , 688692 (2019)

excessive activation in KCs may reduce lipid peroxidation clearance

Research trials reveal that without ongoing treatment or a solid maintenance plan: Hunger levels increase

The FDA also closely reviews how the medication is manufactured to ensure quality from dose to dose

Based on clinical tolerance studies, the recommended maximum daily intake is 0.9 g/kg body weight and should be taken in multiple doses