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10.1016/j.ecoenv.2020.110934 35 IlginS.KilicG.BaysalM.KilicV.KorkutB.UcarcanS.et al (2017)

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SIRT 1 Silent information regulator 1 (SIRT1) is a histone deacetylase that relies on NAD + for regulating various biological functions, including cell proliferation, gene regulation, cellular viability, stress resilience, aging, programmed cell death, and metabolic processes [77]

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Since in vivo and in vitro studies are inconsistent, broader and more detailed studies focused on the mechanisms responsible for oxidative stress modulation under metformin intervention are still needed ( 4.2 In vivo studies In a study by Javadipour et al., a rat model of arsenic-induced diabetes was treated with metformin (dose: 300 mg/kg)