Surgery is generally reserved for cases with progressive neurological deficits, cauda equina syndrome (a surgical emergency), or persistent symptoms despite 6 to 12 months of conservative treatment
In vitro, RBL-2H3 cells pre-treated with luteolin (10 M) showed inhibition of IL-4 expression and mast cell degranulation[164]
But in many cases, it points to something deeper
Cell Biol Toxicol 36:3149 Li W, Pandey AK, Yin X, Chen JJ, Stocco DM, Grammas P, Wang X (2011) Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells
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