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Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

2,97 The EFSA also states that B12 has not been found to be carcinogenic or mutagenic in in vitro and in vivo studies

The strongest evidence involves small older insomnia studies showing modest short-term sleep effects, but no large modern randomized trials have confirmed reliable clinical benefits or established long-term safety

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