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Additionally, PKA-mediated inhibition of protein phosphatase-1 (PP1) alters AMPA and GABAA receptor phosphorylation, influencing neuronal excitability and circuit integrity (Figure 2) (Jancic et al., 2009
A population of SAM with distinct transcriptional signatures has also been reported in the hippocampus of SDS models, enriched for cytokine/chemokine signaling, cellular stress, and phagocytic activity (Goodman et al., 2024)
It is used once daily or several times per week, depending on dosage and individual goals
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