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doi: 10.1210/jc.2014-1425 253

This is usually temporary and occurs because of the shift in the eumelanin-to-pheomelanin ratio we mentioned earlier

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Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1