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Its essential to understand that while semaglutide GLP-1 can be a valuable tool in reducing belly fat, consistent lifestyle modifications, and ongoing support are key to long-term success in managing weight and improving overall health
Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs
Tissue distribution: While both are found in pancreatic beta cells, GLP-1 receptors have a wider distribution in other tissues
Diabetes Res Clin Pract 178:108984
