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As demonstrated in vitro in cultured adipocytes (166, 167) and in vivo in Zucker rats (167), GIP enhances the activity of lipoprotein lipase (LPL), which promotes adipose tissue lipid disposal by enhancing hydrolytic cleavage of circulating triglycerides (TAG) into fatty acids (FA) and monoacylglycerol, which gets re-esterified and stored in adipose tissue
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Gives the skin a visible glow
They randomly assigned participants, none of whom had diabetes, to groups receiving either a standard weekly injection of semaglutide at a dose of 2.4 milligrams, or a higher dose of 7.2 milligrams, or a placebo injection
Tolerability screening The lower systemic exposure from nasal delivery could serve as a tolerability screen before full-dose subcutaneous injection
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