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GLP-1R also contains a caveolin-binding motif in intracellular loop 2 and internalizes in a caveolin-dependent manner (Puddu and Maggi, 2021)
This variability likely reflects differences in underlying pigmentation mechanisms, treatment concentrations, vehicle formulations, and patient populations
doi:10.1016/j.jhep.2015.11.004 17
Depression was the most commonly reported psychiatric adverse event (50.3% of psychiatric reports), followed by anxiety (38.7%) and suicidal ideation (19.6%)
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