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These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)
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MT-II is investigated as a melanocortin receptor agonist (primarily MC1R/MC4R ) for studies spanning melanogenesis , UV/photobiology , energy balance , and neuroendocrine signaling
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