Much of the current evidence comes from laboratory and animal studies, which are encouraging but are not a substitute for large, long-term human clinical trials
Accurate evaluation of cosmetological, dermatological and pharmaceutical products after application on human skin are essential and crucial in product development
Factors affecting injection duration include the underlying cause of deficiency, pregnancy, inflammatory conditions, and medications such as metformin and proton pump inhibitors
Patients reporting "significant energy improvement" rate injections as worth the cost at 2.4x the rate of those reporting "mild improvement." Comparison to alternatives: MIC B12 injections occupy a middle ground: more effective than oral supplementation for B12 repletion and subjective energy, less effective than prescription weight-loss medications for weight reduction, and significantly less expensive than GLP-1 agonists
PMID 18092346)
Some twin pregnancies have higher or faster-rising hCG, but many single pregnancies can rise quickly too