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Additionally, FOXO4-DRI influences antioxidant enzymes such as manganese superoxide dismutase and glutathione peroxidase, further mitigating oxidative stress and promoting cellular health

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Effect sizes were reported as partial for omnibus tests and Cohens d for pairwise comparisons

Cytokine activation has been noted in ME/CFS patients (225) and appears to increase along with disease severity (231)

Triggers can include factors that disrupt the microbiome, dysregulate the immune system, impair metabolic health, or drive inflammation more broadly