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Discussion The study presents a comparative evaluation of DM2 DMTs for their potential in preventing AD comorbidity in DM2 patients

Phase 2 results have been published in The New England Journal of Medicine

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As expected, SURPASS-4 participants had the highest prevalence of CV disease (87%), use of antihypertensive medication at baseline (94%) and lowest estimated glomerular filtration rate (81.3 mL/min/1.73m 2 ), as this study enrolled patients with a high CV risk (coronary heart disease, peripheral arterial disease, cerebrovascular disease, chronic kidney disease or congestive heart failure)